inhibitor of mcl 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12041	MIM1	Inhibitor of Mcl-1	BCL
	MIM1 (Inhibitor of Mcl-1) is an myeloid cell factor 1 (Mcl-1) inhibitor.		BCL
T16156	MT 63-78		Apoptosis , AMPK , mTOR
	MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cel...		Apoptosis , AMPK , mTOR
T5108	ML311		BCL
	ML311 is a selective inhibitor of the Mcl-1/Bim interaction.		BCL
T17247	VU0661013	VU661013	BCL
	VU0661013 is an effective and selective inhibitor of MCL-1.		BCL
T6034	UMI-77	UMI77,UMI 77	BCL
	UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family.		BCL
T10096L	Voruciclib		CDK
	Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ...		CDK
T6650	Sabutoclax	BI-97C1	BCL
	Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.		BCL
T11944	Maritoclax	Marinopyrrole A	BCL
	Maritoclax (Marinopyrrole A) (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value of 10.1 μM.		BCL
T8969	API-1	NSC177223	Akt
	API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .		Akt
T14834	BT2		BCL
	BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 μM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 μM. Its interaction with BDK induces helix movements in the N-terminal domain, l...		BCL
T30969	Clitocine		Apoptosis , BCL
	Clitocine, an adenosine analogue derived from mushrooms, is a potent transcriptional readout agent, an inhibitor of nonsense mutations, and has anticancer activity, inducing the production of p53 protein in cells carryin...		Apoptosis , BCL
T9014	SKI-178		Apoptosis , S1P Receptor
	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...		Apoptosis , S1P Receptor
T12575	Unesbulin	PTC596	Apoptosis , BMI-1
	Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1).		Apoptosis , BMI-1
T6776	BAY 61-3606 dihydrochloride	BAY 61-3606,BAY-61-3606 dihydrochloride	Apoptosis , Syk
	BAY 61-3606 dihydrochloride (BAY 61-3606) is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).		Apoptosis , Syk
T4263	BAY 61-3606	Syk inhibitor IV	Apoptosis , Syk
	BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.		Apoptosis , Syk
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T16694	Pyridoclax	MR-29072	BCL
	Pyridoclax is an inhibitor of potential Mcl-1.		BCL
T72610	Mcl-1 inhibitor 9
	Mcl-1 Inhibitor 9 (Example 2) is a potent inhibitor of myeloid cell leukemia 1 (Mcl-1), demonstrating anti-tumor activity with an IC50 value of 0.21889 nM.
T79036	Mcl-1 inhibitor 13
	Mcl-1 Inhibitor 13 (Example 9), with a Ki of 8.2 nM, serves as an MCL-1 inhibitor suitable for cancer research [1].
T11970	MCL-1/BCL-2-IN-3		Others
	MCL-1/BCL-2-IN-3 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectiely.		Others